α - β Arteether Injection

ARTEV Injection is an antimalarial medication primarily used for the treatment of severe and complicated malaria, particularly malaria caused by *Plasmodium falciparum*, a parasite that is often resistant to other antimalarial drugs. Here are the key uses of ARTEV Injection:

1. Treatment of Severe Falciparum Malar: ARTEV is most commonly used to treat severe cases of *Plasmodium falciparum* malaria, especially in situations where the parasite is resistant to other antimalarial drugs like chloroquine. It is effective in rapidly reducing the parasite load in the bloodstream.

2. Rescue Therapy: In some cases, ARTEV may be used as a rescue therapy for patients who do not respond adequately to first-line antimalarial treatments, or who have relapsed after initial treatment.

3. Treatment of Cerebral Malaria: This medication can be used in the management of cerebral malaria, a life-threatening condition where malaria parasites infect the brain, leading to symptoms such as seizures, coma, and neurological deficits.

Mechanism of Action

ARTEV is a derivative of artemisinin, a compound extracted from the *Artemisia annua* plant. It works by producing free radicals within the parasite after being activated by the iron in the parasite's food vacuole. These free radicals damage the parasites proteins and membranes, leading to its death. ARTEV is particularly effective because it acts rapidly, making it useful in treating severe malaria cases.

Important Considerations

- Dosage and Administration: ARTEV Injection is typically administered intramuscularly. The dosing regimen depends on the severity of the malaria and the patients weight. It should only be used under medical supervision.

- Side Effects: Common side effects include dizziness, nausea, vomiting, and sometimes injection site pain. Serious but rare side effects include cardiotoxicity (heart-related issues), neurotoxicity, and allergic reactions.

- Combination Therapy: Although ARTEV is effective as a standalone treatment, it is often used in combination with other antimalarial drugs to reduce the risk of resistance and to ensure a higher rate of parasite clearance.

- Not for Prophylaxis: ARTEV is not used for the prevention of malaria, only for the treatment of active infections.

ARTEV Injection is a critical medication in the management of severe and drug-resistant malaria, particularly in regions where *Plasmodium falciparum* is prevalent and where rapid treatment is essential to prevent complications and reduce mortality.