Capreomycin for Injection

CAPTIV for Injection is an antibiotic used primarily in the treatment of tuberculosis (TB), especially multidrug-resistant tuberculosis (MDR-TB). It is a second-line drug and is used when first-line treatments are not effective or suitable. Here are the primary uses of Capreomycin for Injection:

 1. Multidrug-Resistant Tuberculosis (MDR-TB)

   - Treatment of MDR-TB: Capreomycin is used as part of a combination regimen to treat multidrug-resistant TB, where the bacteria are resistant to at least isoniazid and rifampin, the two primary first-line TB drugs.

 2. Extensively Drug-Resistant Tuberculosis (XDR-TB)

   - Part of a Regimen for XDR-TB: In cases of extensively drug-resistant TB (XDR-TB), where the bacteria are resistant to additional drugs beyond those targeted in MDR-TB, Capreomycin may be included in the treatment regimen alongside other second-line agents.

Mechanism of Action

Capreomycin works by inhibiting bacterial protein synthesis. It binds to the 70S ribosomal subunit of Mycobacterium tuberculosis, disrupting protein synthesis and leading to bacterial cell death. This mechanism helps in controlling TB infections that are resistant to first-line medications.

Important Considerations

- Side Effects: Capreomycin can cause a range of side effects, including nephrotoxicity (kidney damage), ototoxicity (hearing loss or balance issues), injection site reactions, and gastrointestinal symptoms. Regular monitoring of renal function and hearing is important during treatment.

- Administration: Capreomycin is administered intramuscularly, typically as a daily injection or as prescribed by the treating physician. The dosage and duration of treatment depend on the severity of the TB and the patient's response to therapy.

- Monitoring: Patients on Capreomycin should be monitored for signs of nephrotoxicity and ototoxicity. Regular audiometric tests and kidney function tests are recommended to detect and manage potential adverse effects early.

- Drug Interactions: Capreomycin should be used with caution in combination with other potentially nephrotoxic or ototoxic medications, as this can increase the risk of adverse effects.

CAPTIV for Injection is a crucial component in the treatment of multidrug-resistant and extensively drug-resistant tuberculosis, providing an essential option for managing these challenging cases of TB. Its use requires careful monitoring to minimize potential side effects and ensure effective treatment.