5-Fluorouracil, a potent antimetabolite, is instrumental in treating various cancers, including colorectal, breast, and head and neck cancers. It functions by disrupting DNA and RNA synthesis, impeding cancer cell proliferation. Administered via topical application, it effectively targets actinic keratoses and superficial basal cell carcinomas, offering a non-invasive treatment option. Additionally, Fluorouracil injection plays a pivotal role in palliative care for select cancers, providing symptomatic relief and improving quality of life. Healthcare professionals may recommend its use based on individual patient needs and cancer type. Always follow medical advice and instructions for safe and effective treatment outcomes.